smaniches/uniprot-mcp

What it does

smaniches/uniprot-mcp is an MCP (Model Context Protocol) server that provides comprehensive access to the UniProt knowledgebase through 41 specialized tools. It enables researchers and bioinformaticians to query protein entries, features, variants, post-translational modifications (PTMs), Gene Ontology (GO) terms, and cross-references with full auditability and provenance tracking.

How to set up

Installation is straightforward using uvx command line tool. Run: uvx uniprotmcpserver to launch the server. The tool supports multiple platforms including macOS, Windows, and Linux, making it accessible across different development environments.

Key features

• 41 tools for comprehensive UniProt database querying
• Per-query SHA256 provenance tracking for full auditability
• Offline replay functionality for reproducible research
• Support for protein entries, features, and variants
• PTM and GO term annotation access
• Cross-reference database integration
• Open-source implementation
• Cross-platform compatibility (Python-based)